产品货号：
GS4360
中文名称：
重组人IL-1α
英文名称：
Recombinant Human Interleukin-1 alpha
产品规格：
2μg|10μg
发货周期：
1～3天
产品价格：
询价
General Description
Interleukin-1 alpha (IL-1α) is a non-secreted proinflammatory cytokine produced mainly by activated macrophages,as well as neutrophils,epithelial cells,and endothelial cells.It possesses metabolic,physiological,haematopoietic activities,and plays one of the central roles in the regulation of the immune responses.Both IL-1α and IL-1β binds to the same receptor and has similar identical biological properties.Among various species,the amino acid sequence of mature IL-1α is conserved 60% to 70% and human IL-1 has been found to be biologically active on murine cell lines.IL-1α recently started to find effective application in cosmetic and dermatological formulations,which allow to significantly harmonizing derma architecture.
Storage
This lyophilized preparation is stable at 2～8℃,but should be kept at -20℃ for long term storage,preferably desiccated.
Upon reconstitution,the preparation is stable for up to one week at 2～8℃.For maximal stability,apportion the reconstituted preparation into working aliquots and store at -20℃ to -70℃.Avoid repeated freeze/thaw cycles.
Usage
This material is offered by bjbalb Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
Molecular Weight
Approximately 18.0kDa,a single non-glycosylated polypeptide chain containing 159 amino acids.
Purity
＞97% by SDS-PAGE and HPLC analyses.
Source
Escherichia coli.
Biological Activity
Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0pg/mL,corresponding to a specific activity of ＞ 1.0×109 IU/mg.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2μm filtered concentrated solution in PBS,pH7.4.
Endotoxin
Less than 1.0 EU/μg of rHuIL-1α as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1～1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.
Further dilutions should be made in appropriate buffered solutions.
AA Sequence
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL
TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY
VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN
YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
相关搜索：重组人IL-1α，IL-1α，白细胞介素1α，白介素1α，Recombinant Human Interleukin-1 alpha
Interleukin-1 alpha (IL-1α) is a non-secreted proinflammatory cytokine produced mainly by activated macrophages,as well as neutrophils,epithelial cells,and endothelial cells.It possesses metabolic,physiological,haematopoietic activities,and plays one of the central roles in the regulation of the immune responses.Both IL-1α and IL-1β binds to the same receptor and has similar identical biological properties.Among various species,the amino acid sequence of mature IL-1α is conserved 60% to 70% and human IL-1 has been found to be biologically active on murine cell lines.IL-1α recently started to find effective application in cosmetic and dermatological formulations,which allow to significantly harmonizing derma architecture.
Storage
This lyophilized preparation is stable at 2～8℃,but should be kept at -20℃ for long term storage,preferably desiccated.
Upon reconstitution,the preparation is stable for up to one week at 2～8℃.For maximal stability,apportion the reconstituted preparation into working aliquots and store at -20℃ to -70℃.Avoid repeated freeze/thaw cycles.
Usage
This material is offered by bjbalb Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
Molecular Weight
Approximately 18.0kDa,a single non-glycosylated polypeptide chain containing 159 amino acids.
Purity
＞97% by SDS-PAGE and HPLC analyses.
Source
Escherichia coli.
Biological Activity
Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0pg/mL,corresponding to a specific activity of ＞ 1.0×109 IU/mg.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2μm filtered concentrated solution in PBS,pH7.4.
Endotoxin
Less than 1.0 EU/μg of rHuIL-1α as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1～1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃.
Further dilutions should be made in appropriate buffered solutions.
AA Sequence
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL
TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY
VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN
YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
相关搜索：重组人IL-1α，IL-1α，白细胞介素1α，白介素1α，Recombinant Human Interleukin-1 alpha